Tranexamic Acid (TXA) the Science and the Practice
WHO has incorporated Tranexamic Acid into the PPH treatment guidelines. This webinar will review the science and practice of using TXA for the treatment of PPH.
Globally, nearly one-quarter of all maternal deaths are associated with PPH, and, in most low-income countries, PPH is the main cause of maternal mortality. The majority of PPH-associated deaths could be avoided by the use of prophylactic uterotonics during the third stage of labour and timely, appropriate management of PPH. Efforts to prevent and reduce maternal morbidity and mortality due to PPH can reduce the profound global inequities in maternal health outcomes. Health workers, managers, and policymakers need clear, up-to-date, evidence-based recommendations to inform maternal health policies, guidelines, education platforms, and programmes to strengthen maternal care and improve maternal health outcomes. TXA is a competitive inhibitor of plasminogen activation and can reduce bleeding by inhibiting the breakdown of fibrinogen and fibrin clots. Based on evidence for the benefit of TXA in improving trauma care outcomes, WHO’s recommendations for prevention and treatment of PPH issued in 2012 included a conditional recommendation to use TXA for treatment of PPH when uterotonics fail to control the bleeding or the bleeding is thought to be due to trauma