Child Observational Development (ChiDO) Study
The Child Observational Development (ChiDO) Study is a prospective cohort study following ~600 infants across the developmental delay and neurodevelopmental impairment (DD/NDI) risk spectrum related to perinatal asphyxia/neonatal encephalopathy in Harare, Zimbabwe. Aim 1 is to evaluate the validity of several neurodevelopmental assessment tools, including the Prechtl General Movement Assessment (GMA) and the Hammersmith Infant Neurologic Examination (HINE). Both have shown high sensitivity and specificity for cerebral palsy and cognitive delays, but have limited validation in LMICs. This study will also preliminarily evaluate the Global Scales for Early Development (GSED), which were created as validated developmental assessment instruments for population-level and programmatic evaluation of children ages 0 to 3 years from culturally, linguistically and socioeconomically diverse populations. The ChiDO study will be the first to validate GSED’s use for individual-level assessment.