Many healthcare providers in developing countries, including Ghana, have voiced concerns about their lack of preparedness as well as that of their health facilities to handle COVID-19 infections. Some have also expressed fears of being infected as well as the resulting effects on them and their families. Yet, few studies are documenting and examining these in Ghana and Kenya. We are conducting an explanatory sequential mixed-methods study using a cross-sectional online survey followed by in-depth interviews to document these concerns and to examine the associated psychological effects. The findings will guide COVID-19 preparedness and inform the policy debates in Ghana and Kenya.